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nginx/1.1.19The Basic and Clinical Research of Bioactive Glass Repair Bone Defects
作者中文名
河北联合大学
生物活性玻璃,骨缺损,骨修复,锁骨骨折,治疗,骨折愈合
英文关键词
Bioactiveglass,Bonedefect,Bonerepair,Bioactiveglass,claviclefracture,treatmentHealing
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目的:探讨生物活性玻璃对修复大鼠股骨髁腔隙性缺损的促进作用。方法:利用建立SD大鼠(体重约350克左右)股骨髁腔隙性缺损的模型,根据是否有材料植入及植入材料不同分为实验组(骨缺损中植入生物活性玻璃)、对照组(骨缺损中植入自体骨)和空白对照组组(骨缺损中未植入任何材料)。试验指标:(1)生物活性玻璃修复骨缺损的疗效;(2)生物活性玻璃与自体骨修复骨缺损疗效的比较;(3)大鼠对股骨髁直径2毫米的缺损自行修复能力;(4)实验组、对照组分别于术后2周、6周、10周行股骨髁标本的大体观察、组织学观察、扫描电镜观察。空白对照组于术后2周、6周、10周行股骨髁标本的大体观察、组织学观察。结果:生物活性玻璃同自体骨一样能很好地修复骨缺损,实验组与对照组组织学观察两组术后6周、10周骨缺损中新生骨量无明显统计学差异。实验组术后2周扫描电镜观察植入材料与周围正常骨质界限明显,术后6周材料与新生骨结合紧密,边界密度略增高。材料与周围骨质界限趋于模糊。术后10周,生物活性玻璃消失,新生骨质较成熟,与周围骨质界限消失。对照组术后2周植入植入骨与宿主骨界限清楚,术后6周新骨从四周向植入骨长入。术后10周,结合处已有纤维钙化,边界消失。空白对照组术后10周骨缺损处有纤维瘢痕组织生成,仅缺损周边有少量骨质生成,与实验组和对照组有明显统计学差异。结论:(1)生物活性玻璃可以替代自体骨修复骨缺损;(2)大鼠对股骨髁直径2毫米的腔隙性缺损无自行修复能力。目的:分析生物活性玻璃早期植入治疗锁骨骨折的疗效。方法:从2008年7月至2010年1月,从河北联合大学附属骨科医院病案室抽取45例锁骨骨折病历,这些患者均采用切开复位内固定加植骨或植入生物活性玻璃的方法治疗锁骨骨折。所有患者被分为生物活性玻璃组27例和自体骨组18例。前者早期植入生物活性玻璃,后者植入自体骨。结果:所有患者均接受随访6-12个月,平均8个月,直到骨折愈合。骨折平均愈合时间在生物活性玻璃组为平均12.6周,无延迟愈合和骨不连。自体骨为12.0周,无延迟愈合和骨不连。以患者骨折愈合时间及肩关节功能恢复情况而评定术后疗效,术后12周生物活性玻璃组优良率为96%,自体骨组优良率为100%。两组在统计学上没有显著性差异(P$$0.05)。结论:生物活性玻璃同自体骨一样能早期植入配合内固定治疗锁骨骨折,能加速骨折愈合,降低延迟愈合或骨不连发生率。
Objective:Investigate the enhancement of the Bioactive glass repair rat femoral condyle of lacunar defects.Methods: Use the Femoral condyle lacunar defect model of established SD rats (weighing about 350 grams), divided the rat into experimental group(bone defects implanted Bioactive glass)、the control group (bone defects implanted with autogenous bone) and the blank control group (didn’t implanted any Material in bone defects)depending on whether implant material and the difference of the implant material. Experimental indicators: (1) The curative effect of Bioactive glas(2) The bone defect curative effect Comparison of Bioactive glass and self-(3) self-repair capacity of rats of the femoral condyle defect 2(4)the experimental group and control group respectively after 2 weeks, 6 weeks, 10 weeks, the general line of observation of the femoral condyle specimen observation, histological observation and scanning electron microscopy. The control group after 2 weeks, 6 weeks, 10 weeks of the general line of observation of the femoral condyle specimen observation, histological observation.Results: Both the Bioactive glass and autogenous bone can repair the bone defect, the result between the two groups has no significant difference both in the radiological examination and the histologically observation for the mass of the new bone at 6 weeks and 10 weeks. We found that the implanted material and the normal bone have clear boundaries in 2 who will blur in 6 the Bioactive glass will disappeared and the new bone will more mature ,the boundaries will vanished at 10 weeds through the scanning electron microscope in the experimental group. While the bone of host and bone of impplantation have clear boundaries in 2 the new bone will grow into bone of impp the combined areas will fiber calcification and disappear in 10 weeks in the Control group. However the blank team will appear the histogenesis of fibrous scar and has a few osteosis in the bone defect. So the experimental group and control group was statistically significant.Conclusion: (1) Bioactive glass can replace autogenous bon (2) the femoral condyle defect within 2 mm in diameter on rats has the self-repair capacity. Objective:Analysis of effect on early implantation of Bioactive glass cure clavicle fractures.Methods: From July 2008 to January 2010, selected 45 medical records of clavicle fractures cases randomly from Hebei united University Affiliated Orthopaedic hospital Medical Records Department,all these patients were treated with open reduction and internal fixation with bone grafting or implantation of Bioactive glass. All the patients were randomly divided into two groups,the former group include 27 cases were implanted with Bioactive glass,while the other group include 18 cases were implanted with autologous bone.Results: All patients received follow-up 6 to 12 months, an average of 8 months, until the fracture healed。The average healing time of fracture in Bioactive glass group average of 12.6 weeks, no delayed union and nonunion. The healing time of autologous bone was 12.0 weeks, no delayed union and nonunion.Assessed curative effect of patients with fracture healing time and functional recovery of shoulder after surgery, after 12 weeks the excellent ratio of bioactive glass group was 96% and the autograft group was 100%. The two groups were not statistically significant difference (P $$0.05).Conclusion: Bioactive glass and autologous bone can early implant with internal fixation to treatment fracture, can accelerate fracture healing, reduce the incidence of delayed union and nonunion.
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